Glycobiology & Glycochemistry International E-learning Course

 

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Glycobiology & Glycochemistry International e-learning course

ECTS
20

Coordination
Paula Videira
Amélia Pilar Rauter
Irene Tomé

Organization
NOVA Medical School | Faculdade de Ciências Médicas
Faculdade de Ciências da Universidade de Lisboa

Presentation
Glycoscience has become a vibrant, expanding and important extension of modern molecular biology and medicine. In this course, a team of acknowledged glycoscientists will demonstrate how interdisciplinary areas in Glycosciences have provided solutions and offered tools for demanding health problems. This is the first course in Glycobiology and Glycochemistry, offered in an e-learning format to enhance the outreach of Glycosciences to the broader scientific community. Funded mainly by the Euroglycoforum, this course is also one of the deliverables of the European Innovation Partnership on Active and Healthy Ageing (EIP AHA) – Action Group A3, dedicated to the prevention of functional decline and frailty, built within the EIP AHA A3 consortium by NMS|FCM and FCUL. This Glycobiology and Glycochemistry course aims to create a forum of “scientifically bilingual” investigators fluent in glycan chemistry and biology that will sustain and advance the application of Glycosciences to human health..

Aims
In general, this course aims to provide an easy-to-understand, succinct, and current overview of the fundamental facts, concepts, and methods in Glycosciences. It aims to encourage research in Glycosciences, by revealing the complex involvement of glycans in distinct human-related physiological and pathological conditions.
Successful learners will be able to:
- Describe the different types of glycans, their structure and function
- Understand the contribution of glycochemistry for the access to novel glycans
- Design methodologies / technologies to analyse glycan structures or glycan biosynthesis.
- Discuss subjects within the scope of Glycosciences.
- Explain the relationship between glycan structures and certain pathological conditions.
- Identify glycans used as therapeuticals and glycan-based therapies

Program
The course will be built through the Moodle e-Learning platform. It will start by a 2 hour session tutorial of the e-learning platform, the course aims and evaluation. The course runs 7 weeks and it will be equivalent to 560 hours of full-time study which includes online lectures, reading, exercises, online assignments, and examinations and also the preparation of a written report. The online lectures, consisting on video and slide presentations (ca. 40 lectures) will form the basis of the course. Throughout the course, exercises will be given, designed to improve learning of the various topics in the course. These will not be considered for the final course evaluation, but will form the basis for discussions. Furthermore, successful completion of these exercises will greatly improve chances for success on the final examination.

Carbohydrate structure-function relationships will be highlighted, especially in human physiology and pathology. The importance of “glycomaterials” in understanding biological processes, controlling disease, and preserving human health will be presented and be a focus of discussion. Specific examples will be presented to highlight the interplay of chemistry and biology in maintaining normal physiology and in manipulation of disease processes.
The following modules are included:
Module 1 - Carbohydrate Structure and Nomenclature
Module 2 - Biosynthesis, Metabolism of Carbohydrates
Module 3 - Glycan-binding Proteins
Module 4 - Glycans in Human Physiological Mechanisms
Module 5 - Glycans in Human Pathology
Module 6 - Methods in Glycosciences
Module 7 - Applications of Glycosciences
Module 8 - Glycochemistry in Medicine
Module 9 - Biosynthesis of disease related carbohydrate antigens
Module 10- Glycomics

Assessment Methods
The learner’s final grade in the course will be based on performance along the activities included in the course and also on a final online examination under time control and/or a report. The examination will consist exclusively of short-answer questions which will test the overall comprehension of the various topics covered in the course. The final report will consist on a critical review (limited to 30 pages) or highlights (limited to 15 pages) covering one year or up to 5 years on a particular subject of Glycobiology and/or Glycochemistry research. These highlights are particularly important in presenting the latest findings and the innovation concerning carbohydrate chemistry and biology. The publication ofthese highlights in the Royal Society of Chemistry Specialist Periodical Reports entitled Carbohydrate Chemistry – Chemical and Biological Approaches can be considered upon request to the Editors after submission to refereeing processes.

Coordinatiors
NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa
Paula Videira
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URL: http://cedoc.unl.pt/glycoimmunology/

• Assistant Researcher at NOVA Medical School / Faculdade de Ciências Médicas (NMS/ FCM), NOVA University of Lisbon (UNL). Since September 2014.
• Assistant Professor at Faculdade de Ciências e Tecnologia (FCT), NOVA University of Lisbon (UNL).
Since September 2014.
• Group leader of the
Glycoimmunology group at Chronic Diseases Research Center (CEDOC). NMS/FCM-UNL. Since 2007.
• Fulbright Professor - Harvard Institutes of Medicine, Boston USA. Since 2013.
• Coordinator of the Glycoscience e-learning post graduate course. Since 2012.
• Member of Scientific council of NMS/FCM-UNL, since 2010.
• Scientific coordinator of the Cell Biology Services @ CEDOC
, since 2012.
• Responsible for Scientific Occupancy of Young on Holydays at NMS/FCM (Ciência Viva Program).

Paula has graduated in Biochemistry at the University of Coimbra, in Portugal (1995), and got a Master degree (1998) and a Ph.D. degree (2002) in Biotechnology at Instituto Superior Técnico, Lisbon. She is the group leader of the Glycoimmunology Group and she receives regular funding and presently she coordinates multidisciplinary projects in Glycosciences that also involve clinicians and Biotechnology and Pharma companies, such as Crioestaminal (aDVANCE funded by ADI) and Bluepharma (DeCellMab funded by Bluepharma&UC award).The aim of the group is to establish novel immunotherapeutics, creating proprietary Intellectual Property but also prompting the initiation of clinical trials. Internationally, Paula was awarded by i) the Institute Advanced Study, University of Bologna (2006), ii) by EMBO- European Molecular Biology Organization with a Short Term Fellowship (2011) and iii) by the Fulbright Commission (2013) with a Professor visiting fellowship. Nationally, she has been awarded by Santander&UNL (2013) and Bluepharma&UC (2014) awards. After her award by the Fulbright Commission, she has been an invited researcher at Brigham and Women's Hospital - Harvard Institutes of Medicine, in Boston USA.

Her teaching activities include the coordination of courses to pre and post-graduate students, such as: the “Immunology” course to the first degree at FCT, UNL. She is regent of the “Molecular Immunology”, “Innovative Immunotherapies” and “Molecular Mechanisms of Disease” to Master students (Master Biochemistry for Health and Integrated Master in Medicine, NMS/FCM-UNL). Since 2013, she coordinates several Modules within the doctoral Medicine PhD Program and in 2014, she organized the EMBO Workshop “Glycobiology and glycochemistry: Applications to human health and disease”, http://events.embo.org/14-glyco/ .

Paula is member of the following organizations:

Consortium for Functional Glycomics, from the NIGMS;
International Glycobiology Society;
American Association of Immunologists;
NIH Tetramer Facility;
Portuguese Immunology Society;
Portuguese Society of Congenital Disorders of Glycosylation and other metabolic diseases, Portuguese Biochemistry Society;
Science Advisory Board;
She is reviewer in many journals and Editor at the World Journal of Clinical Urology and
the Journal of Cancer Metastasis and Treatment.

She supervises several pHD students, three post-docs and three master students.
She has presently more than 40 publications in peer reviewed international journals
http://www.ncbi.nlm.nih.gov/pubmed/?term=videira%20p

Faculdade de Ciências, Universidade de Lisboa
Amélia Pilar Rauter
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URL: http://webpages.fc.ul.pt/~aprauter/

- Associate Professor with Habilitation at Faculdade de Ciências, Universidade de Lisboa,

- Founder member of the Center of Chemistry and Biochemistry of Faculdade de Ciências, Universidade de Lisboa and Head of its Carbohydrate Chemistry Group
She was Assistant Professor of the Technische Universität Graz – Austria and her promotion to Doktor der Technischen Wissenschaft of the Technische Universität Graz – Austria was in 1982 under supervision of Prof. Hans Weidmann. After one more year, she came back to Portugal and followed her carrier at the Universidade de Lisboa, where she made the Habilitation (Agregação) at the group of Chemistry of Faculdade de Ciências, Universidade de Lisboa. She was awarded as invited professor of Université Pierre et Marie Curie –Sorbonne Universités, Paris, France (2013), of Polish Academy of Sciences, Warshaw, Poland (2009) and of Université Paris Sud 11, Orsay, France (2009).

Some honorary appointments:

- Editorial activities: Editor of the Royal Society of Chemistry Book Series Carbohydrate Chemistry Chemical and Biological Approaches, member of the Advisory Board of the European Journal of Organic Chemistry, and Associate Editor of Journal of Mediterranean Chemistry.
- Secretary of the European Carbohydrate Organisation (ECO)
- Titular member of IUPAC Division of Chemical Nomenclature and Structure Representation (Division VIII), Associate member of IUPAC Division of Organic and Biomolecular Chemistry (Division III) and Secretary of its Subcommittee on Biomolecular Chemistry
- Member of the Steering Committee and Executive for Glycochemistry of the ESF Research Network Euroglycoforum (2009-2014)
- Member of the European Innovation Partnership on Active and Healthy Ageing (EIP AHA) Action Group 3 – Prevention of functional Decline and Frailty and leader of its FCUL Consortium comprising ca 30 institutions from academia and industry from Portugal, Spain, Italy, and France.
- Member of the COST Action CM1102 entitled “Multivalent Glycosystems for Nanoscience MultiGlycoNano”

In Portugal she has funded the Group of Carbohydrates of the Portuguese Society of Chemistry, has created the specialization of Health and Nutrition of the Master in Chemistry of FCUL, has created, coordinates (and teaches) the courses entitled Carbohydrate Chemistry, lectured in the Graduation in Chemistry (3rd year), and Molecular Glycobiology (Master in Chemistry, Health and Nutrition), and also Organic Chemistry I (1st year, Graduation in Chemistry).

Research interests: Sustainable chemistry for functional molecules based on carbohydrates and other natural products. She supervised 18 Ph.D. students and currently, 6 Ph.D. students are developing their Ph.D. thesis under her supervision.
Publications: She has ca 140 publications, 7 patents and 6 submitted.

Faculdade de Ciências Sociais e Humanas da Universidade Nova de Lisboa
Irene Tomé
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URL: http://www.fcsh.unl.pt/faculdade/docentes/mit


Irene Tomé é doutorada pela Universidade Nova de Lisboa em Ciências da Educação, especialidade de Teoria Curricular e Metodologia de Ensino. Licenciou-se em História pela Faculdade de Ciências Sociais e Humanas da Universidade Nova de Lisboa e obteve o grau de mestre pela mesma instituição.

Na Faculdade de Ciências Sociais e Humanas da Universidade Nova de Lisboa desempenha as funções de:
- investigadora integrada no CITI - Centro de Investigação para Tecnologias Interactivas (http://www.citi.pt
);
- investigadora colaboradora no CESNOVA-Centro de Estudos de Sociologia da Nova
(http://cesnova.fcsh.unl.pt/
);
- professora no Mestrado em Gestão de Sistemas de e-Learning , FCSH-UNL
(http://www.citi.pt/mestrado/);
Tem participado em várias Conferências, Colóquios e é autora de vários trabalhos sobre os sistemas de ensino-aprendizagem utilizados em contexto on-line, bem como na na área da investigação histórica.

Para mais informações, consultar: http://www.citi.pt/irenetome

Other Professors
- Alexandre Ferreira - Institute of Oncology of Porto, Portugal.
- Amélia Pilar Rauter -Faculdade de Ciências, Universidade de Lisboa, Portugal.
- Angelina Palma - REQUIMTE/CQFB Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal.
- Anne Dell - Imperial College, London, UK .
- Anne Imberty - Centre de Recherches sur les Macromolécules Végétales, Centre National de la Recherche Scientifique. Grenoble, France.
- Antonio Molinaro - Università di Napoli "Federico II", Napoli, Italy.
- Antoni Planas - Universitat Ramon Llull, Spain.
- Catherine Ronin - SiaMed'Xpress, Université de Provence, Marseille, France.
- Celso Reis - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal
- Christelle Breton - Centre de Recherches sur les Macromolécules Végétales, Centre National de la Recherche Scientifique.
Grenoble, France.
- Dirk Lefeber - Radboud University Nijmegen Medical Centre, Netherland.
- Fabio Dall'Olio - Faculty of Medicine, Bologna University, Italy.
- Hans H. Wandall - University of Copenhagen, Denmark
- Guadalupe Cabral - Portugal
- Inês Ferreira - Portugal
- Jesus Jiménez Barbero - Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
- Joy Burchel - King’s College London, UK.
- Jaak Jaeken - University Hospital Gasthuisberg, Leuven, Belgium.
- Joseph Lau - Roswell Park Cancer Institute, Buffalo, USA.
- Koichi Fukase - Graduate School of Science, Osaka University, Osaka, Japan.
- Marco Trinchera - The University of Insubria, Italy.
- Michaela Wimmerova - Central European Institute of Technology, Czech Republic.
- Paula Videira - NOVA Medica School/ Faculdade de Ciências Médicas, Universidade Nova de Lisboa.
- Philippe Delannoy - Université des Sciences et Technologies de Lille, France
- Richard Schmidt - Germany
- Robert Sackstein - Director, Program of Excellence in Glycosciences, Harvard Medical School, USA.
- Rui Vitorino - University of Aveiro, Portugal.
- Sabine Flitsch - The University of Manchester, UK
- Stefan Oscarson - University College Dublin, Ireland.
- Serge Perez - Centre de Recherches sur les Macromolécules Végétales, Centre National de la Recherche Scientifique. Grenoble, France.
- Ten Feizi - Imperial College, London, UK.
- Vanessa Ferreira, PhD – CDG Portuguese Association and other metabolic rare diseases (APCDG-DMR), Portugal.
- Yves Queneau - Centre National de la Recherche Scientifique, Lyon, France.
- Yvette Van Kooyk - Department of Molecular Cell Biology & Immunology Vumc, Netherland

Scientific coordinators
- Paula Videira - NOVA Medica School/ Faculdade de Ciências Médicas, Universidade Nova de Lisboa.
- Amélia Pilar Rauter -Faculdade de Ciências, Universidade de Lisboa, Portugal.
- Celso Reis - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal.
- Serge Perez - Centre de Recherches sur les Macromolécules Végétales, Centre National de la Recherche Scientifique. Grenoble, France.
- Angelina Palma - REQUIMTE/CQFB Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Portugal.
- Nuno Xavier - Faculdade de Ciências, Universidade de Lisboa, Portugal

Target
The course is designed to train pre- and post-doctoral scientists, within areas related with Chemistry or Biology. It also includes physicians and educators interested in furthering Glycosciences: This course aims to build upon and compliment the participant’s previous knowledge of chemistry, molecular and cellular biology.

Admission criteria
Curriculum vitae and motivation letter

Numerus Clausus
Número mínimo: 6
Número máximo: 30

Course Dates
May, 4th 2015

Information and registration

Academic Office - Postgraduate Section
Campo Mártires da Pátria, 130 - 1169-056 Lisboa
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Tel.: 21 880 30 66 | Fax: 21 880 30 68

Application Form